منابع مشابه
Identification of genetic variants associated with response to statin therapy.
OBJECTIVE The purpose of this study was to test the association between polymorphisms in genes involved in either LDL cholesterol (LDL-C) metabolism or statin pharmacokinetics and LDL-C reduction with statins. METHODS AND RESULTS 49 tagging and candidate polymorphisms in 9 genes were genotyped in 1507 post-ACS subjects randomized to atorvastatin or pravastatin. Two polymorphisms (rs7412, rs42...
متن کاملLc-ms Strategies in Monitoring the Response to Different Therapy
Therapeutic drug monitoring is an esential tool for a positive management therapy. The prefered laboratory strategy is immunoassay. Due to the cross-reactivity to other components, alternative approaches, such as LC-MS, are continously under investigation. The paper described briefly the main aspects regarding LC-MS apparatus and technique and recent applications on therapeutic drug monitoring,...
متن کاملThe Controversies of Statin Therapy
The debate whether statins, 3-hydroxymethyl-3-methylglutaryl coenzyme A reductase inhibitors, are safe to use has been raging since their introduction in 1987. Statins are generally well tolerated and are believed to have minimal adverse effects. However, individual, specific rare adverse events have been reported, such as elevations of liver enzymes, muscle aches, and very rarely, rhabdomyolys...
متن کاملEffects of statin use on the response duration to androgen deprivation therapy in metastatic prostate cancer
PURPOSE To determine whether statin use delays the development of castration-resistant prostate cancer (CRPC) in patients with metastatic prostate cancer treated with androgen deprivation therapy (ADT). MATERIALS AND METHODS A total of 171 patients with metastatic prostate cancer at the time of diagnosis who were treated with ADT between January 1997 and December 2013 were retrospectively ana...
متن کاملAtheroma progression in hyporesponders to statin therapy.
OBJECTIVE Lowering low-density lipoprotein cholesterol (LDL-C) with statins has been demonstrated to slow plaque progression. This antiatherosclerotic effect in patients with minimal LDL-C lowering has not been investigated. APPROACH AND RESULTS Six hundred forty-seven patients with angiographic coronary artery disease who were commenced on statin therapy underwent serial imaging with intrava...
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ژورنال
عنوان ژورنال: JACC: Cardiovascular Imaging
سال: 2018
ISSN: 1936-878X
DOI: 10.1016/j.jcmg.2018.05.013